What is HIV & AIDS?
HIV is stands for Human Immunodeficiency Virus. The HIV virus can lead to immune deficiency syndrome Called AIDS (Acquired Immunodeficiency Virus).
Is there more then 1 type of HIV Virus?
Yes, there are 2 types of HIV Virus; HIV-1 & HIV-2 Both
types of HIV damage a person’s body by destroying specific blood cells,
called CD4+ T cells, which are crucial to helping the body fight
diseases.
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Electron microscope image of HIV
The small green spheres on the surface of white blood cells.
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Were did HIV/AIDS come from?
For
many years scientists theorized as to the origins of HIV and how it
appeared in the human population, most believing that HIV originated in
other primates. Then in 1999, an international team of researchers
reported that they had discovered the origins of HIV-1, the predominant
strain of HIV in the developed world.
Scientists identified a
type of chimpanzee in West Africa as the source of HIV infection in
humans. They believe that the chimpanzee version of the immunodeficiency
virus (called simian immunodeficiency virus or SIV) most likely was
transmitted to humans and mutated into HIV when humans hunted these
chimpanzees for meat and came into contact with their infected blood.
Over decades, the virus slowly spread across Africa and later into other
parts of the world.
How is HIV spread?
Most common ways of transmitting / getting HIV
- Unprotected Sex
- Having
multiple sex partners or the presence of other sexually transmitted
diseases (STDs) can increase the risk of infection during sex.
- Sharing needles, syringes, rinse water, or other equipment used to prepare illicit drugs for injection.
- Being born to an infected mother—HIV can be passed from mother to child during pregnancy, birth, or breast-feeding.
Less Common ways of transmitting / getting HIV
- Being “stuck” with an HIV-contaminated needle or other sharp object. This risk pertains mainly to healthcare workers.
- Receiving
blood transfusions, blood products, or organ/tissue transplants that
are contaminated with HIV. This risk is extremely remote due to the
rigorous testing of the U.S. blood supply and donated organs/tissue.
- HIV
may also be transmitted through unsafe or unsanitary injections or
other medical or dental practices. However, the risk is also remote
with current safety standards in the U.S.
- Eating
food that has been pre-chewed by an HIV-infected person. The
contamination occurs when infected blood from a caregiver’s mouth mixes
with food while chewing. This appears to be a rare occurrence and has
only been documented among infants whose caregiver gave them pre-chewed
food.
- Being
bitten by a person with HIV. Each of the very small number of cases has
included severe trauma with extensive tissue damage and the presence of
blood. There is no risk of transmission if the skin is not broken.
- Contact
between broken skin, wounds, or mucous membranes and HIV-infected blood
or blood-contaminated body fluids. These reports have also been
extremely rare.
- There
is an extremely remote chance that HIV could be transmitted during
“French” or deep, open-mouth kissing with an HIV-infected person if the
HIV-infected person’s mouth or gums are bleeding.
- Tattooing
or body piercing present a potential risk of HIV transmission, but no
cases of HIV transmission from these activities have been documented.
Only sterile equipment should be used for tattooing or body piercing.
- There
have been a few documented cases in Europe and North Africa where
infants have been infected by unsafe injections and then transmitted HIV
to their mothers through breastfeeding. There have been no documented
cases of this mode of transmission in the U.S.
How can I prevent myself from getting the HIV Virus?
- Know
your HIV status. Everyone between the ages of 13 and 64 should be
tested for HIV at least once. If you are at increased risk for HIV, you
should be tested for HIV at least once a year.
- If
you have HIV, you can get medical care, treatment, and supportive
services to help you stay healthy and reduce your ability to transmit
the virus to others.
- If you are pregnant and find that you have HIV, treatments are available to reduce the chance that your baby will have HIV.
- Abstain from sexual activity or be in a long-term mutually monogamous relationship with an uninfected partner.
- Limit
your number of sex partners. The fewer partners you have, the less
likely you are to encounter someone who is infected with HIV or another
STD.
- Correct and consistent condom use. Latex condoms
are highly effective at preventing transmission of HIV and some other
sexually transmitted diseases. “Natural” or lambskin condoms do not
provide sufficient protection against HIV infection.
- Get tested and treated for STDs and insist that your partners do too.
- Male circumcision has also been shown to reduce the risk of HIV transmission from women to men during vaginal sex.
- Do
not inject drugs. If you inject drugs, you should get counseling and
treatment to stop or reduce your drug use. If you cannot stop injecting
drugs, use clean needles and works when injecting.
- Obtain
medical treatment immediately if you think you were exposed to HIV.
Sometimes, HIV medications can prevent infection if they are started
quickly. This is called post-exposure prophylaxis.
- Participate
in risk reduction programs. Programs exist to help people make healthy
decisions, such as negotiating condom use or discussing HIV status. Your
health department can refer you to programs in your area.
How dose the HIV blood test work?
- Most
HIV tests are antibody tests that measure the antibodies your body
makes against HIV. It can take some time for the immune system to
produce enough antibodies for the antibody test to detect, and this time
period can vary from person to person. This time period is commonly
referred to as the “window period.” Most people will develop detectable
antibodies within 2 to 8 weeks (the average is 25 days). Even so, there
is a chance that some individuals will take longer to develop detectable
antibodies. Therefore, if the initial negative HIV test was conducted
within the first 3 months after possible exposure, repeat testing should
be considered >3 months after the exposure occurred to account for
the possibility of a false-negative result. Ninety-seven percent of
persons will develop antibodies in the first 3 months following the time
of their infection. In very rare cases, it can take up to 6 months to
develop antibodies to HIV.
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- Another
type of test is an RNA test, which detects the HIV virus directly. The
time between HIV infection and RNA detection is 9–11 days. These tests,
which are more costly and used less often than antibody tests, are used
in some parts of the United States.
- There
are also rapid HIV tests available that can give results in as little
as 20 minutes. A positive HIV test result means that a person may have
been infected with HIV. All positive HIV test results, regardless of
whether they are from rapid or conventional tests, must be verified by a
second “confirmatory” HIV test.
What are the symptoms of HIV/AIDS?
When
someone is first infected with HIV, they may have no signs or symptoms
at all, although they are still able to transmit the virus to others.
Many people develop a breif flu-like illness two or four weeks after
becoming infected. Signs and symptoms may include:
- Fever
- Headache
- Sore Throat
- Swollen lymph glands
- Rash
Years LaterA
person may remain symptom-free for years, but as the virus continues to
multiply and destroy immune cells, the person may develop mild
infections or chronic symptoms such as:
- Swollen lymph nodes
- Diarrhea
- Weight Loss
- Fever
- Cough and shortness of breath
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What are the stages for HIV/AIDS?
Most of
us are used to thinking of disease in very simple terms: if you feel
sick, you are sick; if you feel healthy, you are healthy. However,
because HIV may begin causing subtle changes in the immune system long
before an infected person feels sick, most doctors have adopted the term
"HIV disease" to cover the entire HIV spectrum, from initial infection
to full-blown AIDS (which is also called "advanced HIV disease").
The
HIV continuum described below is representative of the experience of
many people with HIV. The time that it takes for each individual to go
through these stages varies. For most people, however, the progression
of HIV disease is fairly slow, taking several years from infection to
the development of severe immune suppression.
Following exposure to the virus, HIV enters the bloodstream and begins to take up residence in the cells; this is when HIV infection occurs.
People with HIV are considered to be infectious (able to transmit HIV
to others) immediately after infection with the virus. A person with HIV
is infectious at all times. Also, a person does not need
to have symptoms or look sick to have HIV. In fact, people may look
perfectly healthy for many years despite the fact that they have HIV in
their bodies. The only way to find out if you are infected is by taking
an HIV test.
STAGE 1: Primary HIV infectionIs
the first stage of HIV disease, typically lasting only a week or two,
when the virus first establishes itself in the body. Some researchers
use the term acute HIV infection to describe the period of time between when a person is first infected with HIV and when antibodies (proteins
made by the immune system in response to infection) against the virus
are produced by the body (usually 6 to 12 weeks) and can be detected by
an HIV test.
STAGE 2: Seroconversion
This
term refers to the time when an HIV positive person's immune system
responds to the infection by producing antibodies to the virus. Most
people develop antibodies within three months after infection, and some
can take up to six months. If an antibody test is done before
seroconversion is complete, it may give a "false negative" result
because sufficient antibodies have not yet been developed by the body. A
three-month window period between infection and production of
antibodies is normal for most of the population. Very, very rarely (i.e., in only a few cases ever),
a person may take six months to produce antibodies. To be certain of
your HIV status, take an HIV antibody test three months or longer after
you were exposed to the virus. For even greater certainty, get tested
again six months after the exposure occurred.
STAGE 3: The Asymptomatic StageAfter
the acute stage of HIV infection, people infected with HIV continue to
look and feel completely well for long periods, usually for many years.
During this time, the only indication that you are infected with HIV is
that you will test positive on standard (antibody) HIV tests and you may
have swollen lymph glands. This means that you look and feel healthy
but can infect other people through unprotected sex or through needle
sharing -- especially if you have not been tested and do not know that
you are infected. Even though an infected person may appear perfectly
healthy, HIV is still very active and is continuing to weaken the immune
system during this stage. In some individuals, the virus appears to
slowly damage the immune system
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over a number of
years. In most people, however, a faster decline of the immune system
occurs at some point, and the virus rapidly replicates. This damage can
be seen in blood tests before any actual symptoms are experienced.
STAGE 4: Early- and Medium-Stage HIV Symptomatic Disease
When
the immune system is compromised by HIV infection, many people begin to
experience some mild HIV disease symptoms, such as skin rashes,
fatigue, night sweats, slight weight loss, mouth ulcers, and fungal skin
and nail infections.Most, though not all, will experience mild symptoms
such as these before developing more serious illnesses. Although one's
prognosis varies greatly depending on a number of factors, it is
generally believed that it takes five to seven years for the first mild
symptoms to appear. These symptoms mark the early and medium stages of
HIV symptomatic disease. As the disease progresses, some individuals may
become quite ill even if they have not yet been diagnosed with AIDS,
the late stage of HIV disease. Typical problems include chronic oral or
vaginal thrush (a fungal rash or spots), recurrent herpes blisters on
the mouth (cold sores) or genitals, ongoing fevers, persistent diarrhea,
and significant weight loss. These symptoms are not necessarily
specific to HIV or the development of AIDS. However, they should be of
concern to people who have tested positive for HIV. Usually, symptoms
occur when the virus has already caused considerable damage to the
immune system. For that reason, people with HIV should not wait until
symptoms appear to get medical treatment. Also, people with high risk
for HIV infection should not wait to for symptoms to appear before
getting tested.
STAGE 5: Late-Stage HIV Disease (AIDS)Receiving
an AIDS diagnosis does not necessarily mean that the diagnosed person
will die soon; some people have lived for many years after their
diagnosis. This is even more the case today with the availability
of highly active antiretroviral therapy (HAART), which has helped extend
the lives of thousands of people living with HIV and AIDS. In addition,
many opportunistic infections can be prevented or treated successfully.
This has substantially increased the longevity and quality of life of
people living with HIV/AIDS. Does everyone who has HIV eventually
develop AIDS? We don't know for certain. Studies show that the majority
of untreated people do eventually become ill from HIV.
However, with regular medical care and other positive lifestyle
factors, such as emotional support, many long-term survivors have been
living with HIV/AIDS for upwards of two decades. As existing treatments
are used earlier in the course of HIV disease and new treatments are
developed, it has become possible to further postpone, and perhaps even
prevent, illness.
What are the treatment options for HIV/ADIS
Usually, the CD4 test is used to determine when a person should start treatment.A
CD4 test measures the number of T-helper cells (in a cubic millimetre
of blood) which is known as a CD4 count. Someone who is not infected
with HIV normally has between 500 and 1200 cells/mm3. In a person
infected with HIV, the CD4 count often declines over a number of years.
HIV
drug treatment is generally recommended when the CD4 test shows fewer
than 350 cells/mm3. World Health Organization (WHO) 2010 guidelines
recommend starting treatment for all patients with CD4 counts of <350
cells/mm3 in all countries. Although most resource-limited countries
aim to follow these guidelines, a number still observe the WHO's 2006
guidelines, which recommend starting treatment at less than 200
cells/mm3.Treatment includes:
- Antiretrovirals,
also know as ARVs, anti-HIV or anti-AIDS drugs - The aim of
antiretroviral treatment is to keep the amount of HIV in the body at a
low level. This stops any weakening of the immune system and allows it
to recover from any damage that HIV might have caused already; This Main
type of treatment option for HIV Virus.
- Combination of three or
more anti-HIV drugs is sometimes referred to as Highly Active
Antiretroviral Therapy (HAART). Doctor tend to use his type of treatment
because if a person infected with HIV only used one drug , the HIV
would quickly become resistant to it and the drug would stop working.
Taking two or more antiretrovirals at the same time vastly reduces the
rate at which resistance would develop, making treatment more effective
in the long term.
- First & second Line Therapy - At
the beginning of treatment, the combination of drugs that a person is
given is called first line therapy. If after a while HIV becomes
resistant to this combination, or if side effects are particularly bad, then a change to second line therapy is usually recommended. Second
line therapy will ideally include a minimum of three new drugs, with at
least one from a new class, in order to increase the likelihood of
treatment success.
HIV/AIDS Facts & Statistics
- Yo
cannot get Aids by hugging or kissing someone (unless you are "french
Kissing" someone with HIV/AIDS, even then it is rare for someone to
contract the HIV Virus)
- There are more than 20 approved antiretroviral drugs but not all are licensed or available in every country
- There are five groups of antiretroviral drugs
- Since 1990, the global number of people leaving with HIV has increased.
- In year 2009, the number started decreasing and are now about the same as in 2007.
- By then end of 2010 there are 34 million people infected with the HIV Virus, compared
- to back in 1990 when only 8 million were infected world wide.
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America Vs. Africa
- HIV in
America Unless otherwise noted, the term “HIV” primarily refers to
HIV-1, however the first case of HIV-2 infection in the United States
was diagnosed in 1987.
- During 2009,
there were an estimated 42,959 new diagnoses of HIV infection in the 40
states and five dependent areas. Adult or adolescent males accounted for
three-quarters of new HIV diagnoses. The main transmission route among
males was male-to-male sexual contact (74%), followed by heterosexual
contact (14%) and injecting drug use (8%). Among female adult and
adolescents, 84.9% were infected through heterosexual contact and 14.8%
through injecting drug use.
- In 2009
blacks/African Americans made up an estimated 50% of new HIV diagnoses,
whites 27%, and Hispanics/Latinos 19%. HIV was diagnosed in an
estimated 166 children (<13 years at diagnosis) in 2009, all but 35
became infected through mother-to-child transmission.
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- HIV-2 infections
are predominantly found in Africa. West African nations with a
prevalence of HIV-2 of more than 1% in the general population are Cape
Verde, Côte d'Ivoire (Ivory Coast), Gambia, Guinea-Bissau, Mali,
Mauritania, Nigeria, and Sierra Leone. Other West African countries
reporting HIV-2 are Benin, Burkina Faso, Ghana, Guinea, Liberia, Niger,
São Tomé, Senegal, and Togo. Angola and Mozambique are other African
nations where the prevalence of HIV-2 is more than 1%.
- Estimated adult (aged 15-49) HIV prevalence, in 2009 was 6.3%
- Estimated number of people (all ages) living with HIV, 2009, estimate 1500 thousand
- Estimated number of people (all ages) living with HIV, in 2009, low estimate 1300 thousand
- Mother-to-child transmission, Estimated number of women (aged 15+) living with HIV, in 2009, 760 thousand
- Paediatric infections, Estimated number of children (aged 0-14) living with HIV, in 2009, 180 thousand
- Orphans, Children (aged 0-17) orphaned by AIDS, in 2009,
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